CCR5 is characteristic of Th1 lymphocytes
P Loetscher, M Uguccioni, L Bordoli, M Baggiolini… - Nature, 1998 - nature.com
P Loetscher, M Uguccioni, L Bordoli, M Baggiolini, B Moser, C Chizzolini, JM Dayer
Nature, 1998•nature.comCD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon
gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular
pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function
in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the
chemokine receptor CCR3. We have studied the occurrence of two additional chemokine
receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones.
gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular
pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function
in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the
chemokine receptor CCR3. We have studied the occurrence of two additional chemokine
receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones.
Abstract
CD4+ lymphocytes can be assigned to two subsets. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 . We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones.
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