[CITATION][C] Studies on the regulation of hepatic cholesterol metabolism in humans

B Angelin - European journal of clinical investigation, 1995 - Wiley Online Library
European journal of clinical investigation, 1995Wiley Online Library
Cholesterol is a vital structural component of all cellular and intracellular membranes, and
also serves as precursor for steroid hormones and bile acids. The recognition of cholesterol
as an important factor in the pathogenesis of clinically important conditions, such as
atherosclerosis and cholelithiasis, has promoted a vast interest in the formation, transport,
and excretion of cholesterol in humans. The clinical demonstration of a reduced risk of
coronary heart disease in response to lipid-lowering pharmacological interventions [l-31 has …
Cholesterol is a vital structural component of all cellular and intracellular membranes, and also serves as precursor for steroid hormones and bile acids. The recognition of cholesterol as an important factor in the pathogenesis of clinically important conditions, such as atherosclerosis and cholelithiasis, has promoted a vast interest in the formation, transport, and excretion of cholesterol in humans. The clinical demonstration of a reduced risk of coronary heart disease in response to lipid-lowering pharmacological interventions [l-31 has been a particular stimulus to search for new ways to lower plasma cholesterol. The liver is a key element in regulating the amounts of lipoproteins in the circulation [4-71 (Fig. 2). Thus, the liver synthesizes the triglyceride-rich very low
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