Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels
SU Oehen, PS Ohashi, K Bürki, H Hengartner… - Cellular …, 1994 - Elsevier
Expression of self antigen on lymphohemopoietic cells and in the thymus has been shown to
cause tolerance by negative selection. To investigate the role of self antigen expression
levels on the induction of tolerance, we generated transgenic mice expressing the
lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) driven by the H-2K b promoter.
Two mouse lines differing in transgene expression levels were obtained and evaluated for
the induction of tolerance to LCMV-GP. LCMV-GP high (GP hi) expressing animals …
cause tolerance by negative selection. To investigate the role of self antigen expression
levels on the induction of tolerance, we generated transgenic mice expressing the
lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) driven by the H-2K b promoter.
Two mouse lines differing in transgene expression levels were obtained and evaluated for
the induction of tolerance to LCMV-GP. LCMV-GP high (GP hi) expressing animals …