The multi-epitope approach for immunotherapy for cancer: identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial …
I Kawashima, SJ Hudson, V Tsai, S Southwood… - Human immunology, 1998 - Elsevier
One approach to development of specific cancer immunotherapy relies on the induction of
cytotoxic T lymphocytes (CTL) specific for tumor-associated antigens (TAA). Induction of TAA-
specific CTL could be used towards the eradication of established tumors, or to prevent their
dissemination or recurrence after primary treatment. The present study identifies a set of CTL
epitopes from TAA frequently found on solid epithelial tumors such as breast, lung and
gastro-intestinal tumors. Specifically, HLA-A2. 1 binding peptides from the MAGE2, MAGE3 …
cytotoxic T lymphocytes (CTL) specific for tumor-associated antigens (TAA). Induction of TAA-
specific CTL could be used towards the eradication of established tumors, or to prevent their
dissemination or recurrence after primary treatment. The present study identifies a set of CTL
epitopes from TAA frequently found on solid epithelial tumors such as breast, lung and
gastro-intestinal tumors. Specifically, HLA-A2. 1 binding peptides from the MAGE2, MAGE3 …