Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza A virus …
SY Sauma, MC Gammon, MA Bednarek… - Human immunology, 1993 - Elsevier
Experiments were carried out to determine whether complexes between MHC class I
molecules and synthetic peptides are representative of those formed under more
physiologically relevant conditions, with peptides derived intracellularly from processed
antigens. Lysis of cells sensitized with exogenously provided and endogenously generated
peptide analogues of the optimal nonameric peptide 58–66 (GILGFVFTL; derived from the
influenza virus matrix protein) was compared. Endogenous loading was accomplished by …
molecules and synthetic peptides are representative of those formed under more
physiologically relevant conditions, with peptides derived intracellularly from processed
antigens. Lysis of cells sensitized with exogenously provided and endogenously generated
peptide analogues of the optimal nonameric peptide 58–66 (GILGFVFTL; derived from the
influenza virus matrix protein) was compared. Endogenous loading was accomplished by …
