We have previously derived MHC class I (H-2K d) restricted cytotoxic T lymphocytes (CTL)
from BALB/c mice immunized with irradiated sporozoites from Plasmodium (P.) berghei and
P. yoelii. The CTL recognize synthetic peptides corresponding to a region of the
circumsporozoite (CS) protein that is homologous in the two species. In the present study,
we have attempted to induce CS-specific CTL by immunization with those peptides in
incomplete Freund's adjuvant. Only a low level CTL response was detected in BALB/c mice …