Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin, superantigen, or TNF results in TNFR1-and TNFR2-dependent liver toxicity in mice
J Schümann, H Bluethmann, G Tiegs - Immunology Letters, 2000 - Elsevier
Pseudomonas aeruginosa is a potentially dangerous Gram-negative nosocomial pathogen,
causing bacteremia in debilitated patients, and a prominent cause of bacterial cholangitis.
Opportunistic infections with other nosocomial pathogens, eg Staphylococcus aureus, are
common. Hence, multi-intoxication with P. aeruginosa exotoxin A (PEA) and other bacterial
toxins, including endotoxin (LPS) and the superantigen S. aureus enterotoxin B (SEB), is
very likely. Here we show that PEA synergistically interacted with LPS, SEB, or recombinant …
causing bacteremia in debilitated patients, and a prominent cause of bacterial cholangitis.
Opportunistic infections with other nosocomial pathogens, eg Staphylococcus aureus, are
common. Hence, multi-intoxication with P. aeruginosa exotoxin A (PEA) and other bacterial
toxins, including endotoxin (LPS) and the superantigen S. aureus enterotoxin B (SEB), is
very likely. Here we show that PEA synergistically interacted with LPS, SEB, or recombinant …