Myeloperoxidase deficiency
WM Nauseef - Hematology/oncology clinics of North America, 1988 - Elsevier
The potent myeloperoxidase-hydrogen-peroxide-halide (MPO-H 2 O 2-halide) system
created by activated neutrophils represents an extremely efficient microbicidal system.
Nonetheless, hereditary deficiency of MPO is extremely common and only rarely associated
with clinically significant immune dysfunction. In addition, acquired deficiency of MPO is
seen in some forms of myeloid leukemia. The structure and function of MPO are reviewed in
this context, and recent data regarding the biosynthesis of MPO are presented. Current …
created by activated neutrophils represents an extremely efficient microbicidal system.
Nonetheless, hereditary deficiency of MPO is extremely common and only rarely associated
with clinically significant immune dysfunction. In addition, acquired deficiency of MPO is
seen in some forms of myeloid leukemia. The structure and function of MPO are reviewed in
this context, and recent data regarding the biosynthesis of MPO are presented. Current …