Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

JC Erickson, G Hollopeter, RD Palmiter - Science, 1996 - science.org
JC Erickson, G Hollopeter, RD Palmiter
Science, 1996science.org
The obesity syndrome of ob/ob mice results from lack of leptin, a hormone released by fat
cells that acts in the brain to suppress feeding and stimulate metabolism. Neuropeptide Y
(NPY) is a neuromodulator implicated in the control of energy balance and is overproduced
in the hypothalamus of ob/ob mice. To determine the role of NPY in the response to leptin
deficiency, ob/ob mice deficient for NPY were generated. In the absence of NPY, ob/ob mice
are less obese because of reduced food intake and increased energy expenditure, and are …
The obesity syndrome of ob/ob mice results from lack of leptin, a hormone released by fat cells that acts in the brain to suppress feeding and stimulate metabolism. Neuropeptide Y (NPY) is a neuromodulator implicated in the control of energy balance and is overproduced in the hypothalamus of ob/ob mice. To determine the role of NPY in the response to leptin deficiency, ob/ob mice deficient for NPY were generated. In the absence of NPY, ob/ob mice are less obese because of reduced food intake and increased energy expenditure, and are less severely affected by diabetes, sterility, and somatotropic defects. These results suggest that NPY is a central effector of leptin deficiency.
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