[HTML][HTML] Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers
M Molinari, C Galli, N Norais, JL Telford… - Journal of Biological …, 1997 - ASBMB
Intoxication of mammalian cells with the vacuolating toxin (VacA) released by Helicobacter
pyloricauses the formation of large acidic vacuoles containing the vacuolar ATPase proton
pump and Rab7, a late endosome marker. Here, we describe a novel subcellular
fractionation procedure, and we show that nanomolar concentrations of VacA induce a clear
redistribution of lysosomal membrane glycoproteins among endocytic compartments. This
redistribution is an early event in the process of cellular intoxication by VacA and precedes …
pyloricauses the formation of large acidic vacuoles containing the vacuolar ATPase proton
pump and Rab7, a late endosome marker. Here, we describe a novel subcellular
fractionation procedure, and we show that nanomolar concentrations of VacA induce a clear
redistribution of lysosomal membrane glycoproteins among endocytic compartments. This
redistribution is an early event in the process of cellular intoxication by VacA and precedes …