STAT3 regulates the growth and immunoglobulin production of BCL1 B cell lymphoma through control of cell cycle progression
JG Karras, RA McKay, T Lu, J Pych, DA Frank… - Cellular …, 2000 - Elsevier
STAT3 is constitutively phosphorylated on tyrosine705 in self-renewing, CD5+ murine B-1
lymphocytes. Nuclear extracts from untreated primary B-1 or CD5+ BCL1 B lymphoma cells
were found to contain immunoreactive STAT3 protein that binds to a sis-inducible element
present in the promoter of the p21waf1/cip1 tumor suppressor gene and is constitutively
phosphorylated on serine727. To determine the functional significance of constitutive STAT3
activation in B lymphoma cells, a specific STAT3 antisense oligonucleotide was developed …
lymphocytes. Nuclear extracts from untreated primary B-1 or CD5+ BCL1 B lymphoma cells
were found to contain immunoreactive STAT3 protein that binds to a sis-inducible element
present in the promoter of the p21waf1/cip1 tumor suppressor gene and is constitutively
phosphorylated on serine727. To determine the functional significance of constitutive STAT3
activation in B lymphoma cells, a specific STAT3 antisense oligonucleotide was developed …