Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
LV Goodrich, RL Johnson, L Milenkovic… - Genes & …, 1996 - genesdev.cshlp.org
LV Goodrich, RL Johnson, L Milenkovic, JA McMahon, MP Scott
Genes & development, 1996•genesdev.cshlp.orgThe signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies
and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel
transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We
have identified a mouse homolog of ptc which in many tissues is transcribed near cells
making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in
the mouse central nervous system induces ptc transcription. As in flies, mouse ptc …
and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel
transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We
have identified a mouse homolog of ptc which in many tissues is transcribed near cells
making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in
the mouse central nervous system induces ptc transcription. As in flies, mouse ptc …
The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.
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