Characterization of a neuronal κB-binding factor distinct from NF-κB
AM Moerman, X Mao, MM Lucas, SW Barger - Molecular brain research, 1999 - Elsevier
Transcription factors that bind κB enhancer elements have begun to garner wide attention in
neurobiology. Data suggest that activation of κB-binding factors in neurons can be protective
against various neurotoxins, but other data have connected NF-κB to cell death. In
electrophoretic mobility shift assays of κB-binding activity, we have found that the
predominant activity in rat brain tissue, in primary neurons, and in neuronal cell lines has a
mobility inconsistent with that of bona fide NF-κB (RelA-p50 heterodimer). We have …
neurobiology. Data suggest that activation of κB-binding factors in neurons can be protective
against various neurotoxins, but other data have connected NF-κB to cell death. In
electrophoretic mobility shift assays of κB-binding activity, we have found that the
predominant activity in rat brain tissue, in primary neurons, and in neuronal cell lines has a
mobility inconsistent with that of bona fide NF-κB (RelA-p50 heterodimer). We have …