[HTML][HTML] Lipoproteins inhibit macrophage activation by lipoteichoic acid
C Grunfeld, M Marshall, JK Shigenaga, AH Moser… - Journal of lipid …, 1999 - ASBMB
Regulation of lipid metabolism during infection is thought to be part of host defense, as
lipoproteins neutralize endotoxin (LPS) and viruses. Gram-positive infections also induce
disturbances in lipid metabolism. Therefore, we investigated whether lipoproteins could
inhibit the toxic effects of lipoteichoic acid (LTA), a fragment of gram-positive bacteria. LTA
activated RAW264. 7 macrophage cells, stimulating production of tumor necrosis factor
(TNF) in a dose-dependent matter, but produced less TNF than that seen after LPS …
lipoproteins neutralize endotoxin (LPS) and viruses. Gram-positive infections also induce
disturbances in lipid metabolism. Therefore, we investigated whether lipoproteins could
inhibit the toxic effects of lipoteichoic acid (LTA), a fragment of gram-positive bacteria. LTA
activated RAW264. 7 macrophage cells, stimulating production of tumor necrosis factor
(TNF) in a dose-dependent matter, but produced less TNF than that seen after LPS …