[HTML][HTML] Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine
CCY Chang, N Sakashita, K Ornvold, O Lee… - Journal of Biological …, 2000 - ASBMB
By using specific anti-ACAT-1 antibodies in immunodepletion studies, we previously found
that ACAT-1, a 50-kDa protein, plays a major catalytic role in the adult human liver, adrenal
glands, macrophages, and kidneys but not in the intestine. Acyl-coenzyme A: cholesterol
acyltransferase (ACAT) activity in the intestine may be largely derived from a different ACAT
protein. To test this hypothesis, we produced specific polyclonal anti-ACAT-2 antibodies that
quantitatively immunodepleted human ACAT-2, a 46-kDa protein expressed in Chinese …
that ACAT-1, a 50-kDa protein, plays a major catalytic role in the adult human liver, adrenal
glands, macrophages, and kidneys but not in the intestine. Acyl-coenzyme A: cholesterol
acyltransferase (ACAT) activity in the intestine may be largely derived from a different ACAT
protein. To test this hypothesis, we produced specific polyclonal anti-ACAT-2 antibodies that
quantitatively immunodepleted human ACAT-2, a 46-kDa protein expressed in Chinese …