[HTML][HTML] Characterization of two human genes encoding acyl coenzyme A: cholesterol acyltransferase-related enzymes
P Oelkers, A Behari, D Cromley, JT Billheimer… - Journal of Biological …, 1998 - ASBMB
The enzyme acyl coenzyme A: cholesterol acyltransferase 1 (ACAT1) mediates sterol
esterification, a crucial component of intracellular lipid homeostasis. Two enzymes catalyze
this activity in Saccharomyces cerevisiae (yeast), and several lines of evidence suggest
multigene families may also exist in mammals. Using the human ACAT1 sequence to screen
data bases of expressed sequence tags, we identified two novel and distinct partial human
cDNAs. Full-length cDNA clones for these ACAT related gene products (ARGP) 1 and 2 …
esterification, a crucial component of intracellular lipid homeostasis. Two enzymes catalyze
this activity in Saccharomyces cerevisiae (yeast), and several lines of evidence suggest
multigene families may also exist in mammals. Using the human ACAT1 sequence to screen
data bases of expressed sequence tags, we identified two novel and distinct partial human
cDNAs. Full-length cDNA clones for these ACAT related gene products (ARGP) 1 and 2 …