[HTML][HTML] E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IκB kinases and nuclear factor κB activities
R Shao, MCT Hu, BP Zhou, SY Lin, PJ Chiao… - Journal of Biological …, 1999 - ASBMB
The adenovirus E1A protein has been implicated in increasing cellular susceptibility to
apoptosis induced by tumor necrosis factor (TNF); however, its mechanism of action is still
unknown. Since activation of nuclear factor κB (NF-κB) has been shown to play an anti-
apoptotic role in TNF-induced apoptosis, we examined apoptotic susceptibility and NF-κB
activation induced by TNF in the E1A transfectants and their parental cells. Here, we
reported that E1A inhibited activation of NF-κB and rendered cells more sensitive to TNF …
apoptosis induced by tumor necrosis factor (TNF); however, its mechanism of action is still
unknown. Since activation of nuclear factor κB (NF-κB) has been shown to play an anti-
apoptotic role in TNF-induced apoptosis, we examined apoptotic susceptibility and NF-κB
activation induced by TNF in the E1A transfectants and their parental cells. Here, we
reported that E1A inhibited activation of NF-κB and rendered cells more sensitive to TNF …