Histidine-proline-rich glycoprotein (HPRG), also known as histidine-rich glycoprotein, is a
major plasminogen-binding protein. In this work we characterized extensively the
circumstances under which HPRG accelerates plasminogen activation and the specificity of
this effect. Soluble HPRG did not significantly influence plasminogen activation. In contrast,
native HPRG bound to hydrazide or nickel chelate surfaces strongly stimulated the activation
of plasminogen by tissue plasminogen activator, but not by urokinase or streptokinase. The …