[HTML][HTML] Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of …
L Cominacini, AF Pasini, U Garbin, A Davoli… - Journal of Biological …, 2000 - ASBMB
In this study we examined the effect of oxidized low density lipoprotein (ox-LDL) on the
intracellular production of reactive oxygen species (ROS) in bovine aortic endothelial cells
(BAECs) and whether this increase occurs through its binding to the endothelial receptor
lectin-like ox-LDL receptor-1 (LOX-1). Furthermore, this study also aimed to ascertain
whether the binding of ox-LDL to LOX-1 is associated with NF-κB activation. ox-LDL induced
a significant dose-dependent increase in ROS production after a 30-s incubation with …
intracellular production of reactive oxygen species (ROS) in bovine aortic endothelial cells
(BAECs) and whether this increase occurs through its binding to the endothelial receptor
lectin-like ox-LDL receptor-1 (LOX-1). Furthermore, this study also aimed to ascertain
whether the binding of ox-LDL to LOX-1 is associated with NF-κB activation. ox-LDL induced
a significant dose-dependent increase in ROS production after a 30-s incubation with …