[HTML][HTML] Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4: MD-2 is required for activation of mitogen-activated protein kinases and Elk-1
H Yang, DW Young, F Gusovsky, JC Chow - Journal of Biological Chemistry, 2000 - ASBMB
Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-κB
(NF-κB) activity and the mitogen-activated protein (MAP) kinases, ERK, JNK, and p38 in LPS-
responsive cells, resulting in transcriptional activation and cytokine generation. LPS-induced
signaling via toll-like receptor 4 (TLR4) results in the activation of the transcription factor NF-
κB. Since LPS activates other signaling cascades in responsive cells, the objective of this
study was to determine whether such events are mediated by TLR4 in response to LPS. We …
(NF-κB) activity and the mitogen-activated protein (MAP) kinases, ERK, JNK, and p38 in LPS-
responsive cells, resulting in transcriptional activation and cytokine generation. LPS-induced
signaling via toll-like receptor 4 (TLR4) results in the activation of the transcription factor NF-
κB. Since LPS activates other signaling cascades in responsive cells, the objective of this
study was to determine whether such events are mediated by TLR4 in response to LPS. We …