[HTML][HTML] TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
G Takaesu, S Kishida, A Hiyama, K Yamaguchi… - Molecular cell, 2000 - cell.com
Molecular cell, 2000•cell.com
The TAK1 MAPKKK mediates activation of JNK and NF-κB in the IL-1-activated signaling
pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway
that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-κB
activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1
stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-
dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor …
pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway
that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-κB
activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1
stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-
dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor …
Abstract
The TAK1 MAPKKK mediates activation of JNK and NF-κB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-κB activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1 stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway.
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