Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells
JS Kuniyoshi, CJ Kuniyoshi, AM Lim, FY Wang… - Cellular …, 1999 - Elsevier
Dendritic cells (DC) are professional antigen-presenting cells which stimulate strong
proliferative and cytolytic T cell responses. Stimulation of CD40 on dendritic cells by its
ligands and anti-CD40 antibodies induces maturation and enhances DC stimulatory ability.
In order to understand the mechanism by which ligand: CD40 interactions augment DC
function, we assessed the role of T cell stimulatory cytokines IL-12 and IL-15 in the function
of DC stimulated with soluble trimeric CD40L, a recombinant fusion protein incorporating …
proliferative and cytolytic T cell responses. Stimulation of CD40 on dendritic cells by its
ligands and anti-CD40 antibodies induces maturation and enhances DC stimulatory ability.
In order to understand the mechanism by which ligand: CD40 interactions augment DC
function, we assessed the role of T cell stimulatory cytokines IL-12 and IL-15 in the function
of DC stimulated with soluble trimeric CD40L, a recombinant fusion protein incorporating …