Leptin receptor action in hepatic cells
Y Wang, KK Kuropatwinski, DW White… - Journal of Biological …, 1997 - ASBMB
Leptin, an adipocyte-secreted hormone, is one of the central regulators of body weight
homeostasis. In humans and rodents, two major forms of leptin receptors (OB-R) are
expressed. The short form (OB-R S), considered to lack signaling capability, is detected in
many organs. In contrast, OB-R long form (OB-R L) predominates in the hypothalamus, but is
also present at low levels in peripheral tissues. Transient transfection experiments have
demonstrated that OB-R L transduces an intracellular signaling similar to interleukin (IL)-6 …
homeostasis. In humans and rodents, two major forms of leptin receptors (OB-R) are
expressed. The short form (OB-R S), considered to lack signaling capability, is detected in
many organs. In contrast, OB-R long form (OB-R L) predominates in the hypothalamus, but is
also present at low levels in peripheral tissues. Transient transfection experiments have
demonstrated that OB-R L transduces an intracellular signaling similar to interleukin (IL)-6 …
