[CITATION][C] The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X Chromosome
PJ Blair, DA Carpenter, VL Godfrey, LB Russell… - Mammalian …, 1994 - Springer
PJ Blair, DA Carpenter, VL Godfrey, LB Russell, JE Wilkinson, EM Rinchik
Mammalian Genome, 1994•SpringerIn the mouse, the X-linked recessive mutation scurfy (sO) results in a rapidly fatal
lymphoreticular disease that is characterized by runting, exfoliative dermatitis,
lymphadenopathy, hepatosplenomegaly, thymic atrophy, and severe anemia (Godfrey et al.
1991a). T cells mediate disease in the scurfy mouse (Godfrey et al. 1991b), with CD4+ CD8-
T lymphocytes being the critical effector cells in disease pathogenesis (Blair et al. 1994).
With both repulsion and coupling crosses (Godfrey et al. 1991a), it had been demonstrated …
lymphoreticular disease that is characterized by runting, exfoliative dermatitis,
lymphadenopathy, hepatosplenomegaly, thymic atrophy, and severe anemia (Godfrey et al.
1991a). T cells mediate disease in the scurfy mouse (Godfrey et al. 1991b), with CD4+ CD8-
T lymphocytes being the critical effector cells in disease pathogenesis (Blair et al. 1994).
With both repulsion and coupling crosses (Godfrey et al. 1991a), it had been demonstrated …
In the mouse, the X-linked recessive mutation scurfy (sO) results in a rapidly fatal lymphoreticular disease that is characterized by runting, exfoliative dermatitis, lymphadenopathy, hepatosplenomegaly, thymic atrophy, and severe anemia (Godfrey et al. 1991a). T cells mediate disease in the scurfy mouse (Godfrey et al. 1991b), with CD4+ CD8-T lymphocytes being the critical effector cells in disease pathogenesis (Blair et al. 1994). With both repulsion and coupling crosses (Godfrey et al. 1991a), it had been demonstrated that the scurfy mutation maps near the centromere of the mouse X Chromosome (Chr) within two centimorgans (cM) of sparse fur (spf), a known point mutation within the ornithine transcarbamylase gene (Otc)(Veres et al. 1987).
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