Endotoxin In Vivo Impairs Endothelium-dependent Relaxation of Canine Arteries In Vitro1-3
ME Wylam, RW Samsel, JG Umans, RW Mitchell… - Am Rev Respir …, 1990 - atsjournals.org
ME Wylam, RW Samsel, JG Umans, RW Mitchell, AR Leff, PT Schumacker
Am Rev Respir Dis, 1990•atsjournals.orgWe studied the effect of endotoxin administration/n"/" 0 on arterial smooth muscle
responses/n"/fro, testing the hypotheses that endotoxin augments adrenergic
vasoconstriction and Impairs endothellum-dependent vascular relaxation. Ten mongrel dogs
_re anesthetized and mechanically ventilated. Five received a bolus Infusion of Escher/ch/a
coli endotoxin (5 mg/kg), and the remainder received a sham Infusion. After 4 to 5 h, the
anesthetized dogs _re rapidly exsangUinated, and femoral, renal, and superior mesenteric …
responses/n"/fro, testing the hypotheses that endotoxin augments adrenergic
vasoconstriction and Impairs endothellum-dependent vascular relaxation. Ten mongrel dogs
_re anesthetized and mechanically ventilated. Five received a bolus Infusion of Escher/ch/a
coli endotoxin (5 mg/kg), and the remainder received a sham Infusion. After 4 to 5 h, the
anesthetized dogs _re rapidly exsangUinated, and femoral, renal, and superior mesenteric …
Summary
We studied the effect of endotoxin administration/n"/" 0 on arterial smooth muscle responses/n"/fro, testing the hypotheses that endotoxin augments adrenergic vasoconstriction and Impairs endothellum-dependent vascular relaxation. Ten mongrel dogs _re anesthetized and mechanically ventilated. Five received a bolus Infusion of Escher/ch/a coli endotoxin (5 mg/kg), and the remainder received a sham Infusion. After 4 to 5 h, the anesthetized dogs _re rapidly exsangUinated, and femoral, renal, and superior mesenteric arteries _re removed. Artarlal rings
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