[HTML][HTML] Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2
SR Adderley, DJ Fitzgerald - Journal of Biological Chemistry, 1999 - ASBMB
Oxidative stress causes cardiac damage following ischemia/reperfusion and in response to
anthracyclines. Extracellular signal-regulated kinases (ERK) 1/2 are activated by oxidative
stress in cardiac myocytes and protect cardiac myocytes from apoptosis. Prostaglandins
(PG) also protect cells from injury in a number of tissues, including the cardiomyocyte.
Cyclooxygenase (COX) the rate-limiting enzyme in PG biosynthesis has two isoforms, the
constitutive COX-1 and an inducible COX-2. Here, we examined the effects of two oxidative …
anthracyclines. Extracellular signal-regulated kinases (ERK) 1/2 are activated by oxidative
stress in cardiac myocytes and protect cardiac myocytes from apoptosis. Prostaglandins
(PG) also protect cells from injury in a number of tissues, including the cardiomyocyte.
Cyclooxygenase (COX) the rate-limiting enzyme in PG biosynthesis has two isoforms, the
constitutive COX-1 and an inducible COX-2. Here, we examined the effects of two oxidative …