Liver regeneration

GK Michalopoulos - The liver: biology and pathobiology, 2020 - Wiley Online Library
Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically
modified mice, or response of intact liver in vivo by injecting specific signaling substances.
This chapter discusses these signals with emphasis on their effects on LR. Autophagy
regulation is an important part of LR. Even though LR after partial hepatectomy is not
representative of types of liver injury most commonly seen in liver disease, it has been a very …

Liver regeneration: molecular mechanisms of growth control

GK Michalopoulos - Artificial Liver Support: Concepts, Methods, Results, 1990 - Springer
Liver regeneration was recognized as a spectacular example of controlled tissue growth
ever since the gods of ancient Greece condemned Prometheus to be subjected to daily
partial hepatectomy by a bird, after he stole the secret of fire from the gods and passed it to
the humans. Despite many years of study of liver regeneration, the detailed nature of the
controlling factors which trigger or modulate this phenomenon has only recently started to
become understood. Much progress has been made in the elucidation of the mechanisms …