Elimination of macrophage-specific apolipoprotein E reduces diet-induced atherosclerosis in C57BL/6J male mice
WA Boisvert, LK Curtiss - Journal of lipid research, 1999 - ASBMB
Apolipoprotein (apo) E is synthesized in atherosclerotic lesions by macrophages, however,
its role in lesions is not known. Whereas apoE could exacerbate atherosclerosis by
promoting macrophage uptake of cholesterol-rich lipoproteins or modulating protective
inflammatory responses, it could also restrict lesion formation by facilitating cholesterol efflux
out of lesions. The role of apoE was examined in lethally irradiated male C57BL/6J wild-type
(WT) mice that were repopulated with bone marrow cells (BMT) from either identical …
its role in lesions is not known. Whereas apoE could exacerbate atherosclerosis by
promoting macrophage uptake of cholesterol-rich lipoproteins or modulating protective
inflammatory responses, it could also restrict lesion formation by facilitating cholesterol efflux
out of lesions. The role of apoE was examined in lethally irradiated male C57BL/6J wild-type
(WT) mice that were repopulated with bone marrow cells (BMT) from either identical …
