[HTML][HTML] Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein
G Bu, S Rennke - Journal of Biological Chemistry, 1996 - ASBMB
The 39-kDa receptor-associated protein (RAP) is a receptor antagonist that inhibits ligand
interactions with the receptors that belong to the low density lipoprotein receptor gene
family. Our previous studies have demonstrated that RAP interacts with the low density
lipoprotein receptor-related protein (LRP) within the endoplasmic reticulum and prevents
premature interaction of ligands with the receptor. To analyze whether RAP is also involved
in the folding of LRP during receptor biosynthesis, we generated anchor-free, soluble …
interactions with the receptors that belong to the low density lipoprotein receptor gene
family. Our previous studies have demonstrated that RAP interacts with the low density
lipoprotein receptor-related protein (LRP) within the endoplasmic reticulum and prevents
premature interaction of ligands with the receptor. To analyze whether RAP is also involved
in the folding of LRP during receptor biosynthesis, we generated anchor-free, soluble …