[HTML][HTML] Amyloid β-peptide is transported on lipoproteins and albumin in human plasma
AL Biere, B Ostaszewski, ER Stimson… - Journal of Biological …, 1996 - ASBMB
The amyloid β-peptide (Aβ) is the major constituent of neuritic plaques in Alzheimer's
disease and occurs as a soluble 40-42-residue peptide in cerebrospinal fluid and blood of
both normal and AD subjects. It is unclear whether Aβ, once it is secreted by cells, remains
free in biological fluids or is associated with other proteins and thus transported and
metabolized with them. Such knowledge of the normal fate of Aβ is a prerequisite for
understanding the changes that may lead to the pathological aggregation of soluble Aβ in …
disease and occurs as a soluble 40-42-residue peptide in cerebrospinal fluid and blood of
both normal and AD subjects. It is unclear whether Aβ, once it is secreted by cells, remains
free in biological fluids or is associated with other proteins and thus transported and
metabolized with them. Such knowledge of the normal fate of Aβ is a prerequisite for
understanding the changes that may lead to the pathological aggregation of soluble Aβ in …