[HTML][HTML] Characterization of Apolipoprotein J-Alzheimer's Aβ Interaction (∗)
E Matsubara, B Frangione, J Ghiso - Journal of Biological Chemistry, 1995 - ASBMB
The main component of Alzheimer's amyloid deposits, Aβ, has been found also as a soluble
(sAβ) normal constituent of biological fluids and cell culture supernatants. Whether or not
sAβ is the immediate precursor of Aβ, it is clear that peptides with the same amino acid
sequence can have both fibrillar and non-fibrillar conformations. The interconversion
mechanism from one form to another is presently under intensive investigation. We have
previously described that (i) a synthetic peptide Aβ 1-40 immobilized on affinity matrices was …
(sAβ) normal constituent of biological fluids and cell culture supernatants. Whether or not
sAβ is the immediate precursor of Aβ, it is clear that peptides with the same amino acid
sequence can have both fibrillar and non-fibrillar conformations. The interconversion
mechanism from one form to another is presently under intensive investigation. We have
previously described that (i) a synthetic peptide Aβ 1-40 immobilized on affinity matrices was …