[HTML][HTML] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

WS Simonet, DL Lacey, CR Dunstan, M Kelley… - cell, 1997 - cell.com
WS Simonet, DL Lacey, CR Dunstan, M Kelley, MS Chang, R Lüthy, HQ Nguyen, S Wooden…
cell, 1997cell.com
A novel secreted glycoprotein that regulates bone resorption has been identified. The
protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.
In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal
osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These
same effects are observed upon administration of recombinant OPG into normal mice. In
vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner …
Abstract
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
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