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FP Ross - The Journal of Clinical Investigation, 2000 - Am Soc Clin Investig
FP Ross
The Journal of Clinical Investigation, 2000Am Soc Clin Investig
Regulation of osteoclast formation. A range of hormones and cytokines, targeting to stromal
cells, enhance expression of M-CSF and RANK-L, the pivotal osteoclastogenic molecules,
and the proinflammatory cytokines IL-1, IL-6, and TNF. These proteins stimulate both
formation and activity of mature polykaryons. HSC, hematopoietic stem cell; OC, osteoclast.
Regulation of osteoclast formation. A range of hormones and cytokines, targeting to stromal cells, enhance expression of M-CSF and RANK-L, the pivotal osteoclastogenic molecules, and the proinflammatory cytokines IL-1, IL-6, and TNF. These proteins stimulate both formation and activity of mature polykaryons. HSC, hematopoietic stem cell; OC, osteoclast.
The Journal of Clinical Investigation