Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q Wang, ME Curran, I Splawski, TC Burn… - Nature …, 1996 - nature.com
Q Wang, ME Curran, I Splawski, TC Burn, JM Millholland, TJ VanRaay, J Shen, KW Timothy…
Nature genetics, 1996nature.com
Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here,
positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene
responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly
expressed in the heart and encodes a protein with structural features of a voltage-gated
potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia
families, including one intragenic deletion and ten different missense mutations. These data …
Abstract
Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly expressed in the heart and encodes a protein with structural features of a voltage-gated potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia families, including one intragenic deletion and ten different missense mutations. These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.
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