Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells
LP Zhang, T Takahara, Y Yata, K Furui, B Jin… - Journal of …, 1999 - Elsevier
Background/Aims: Plasminogen activators and plasminogen activator inhibitors are
important regulators of the balance between the proteolytic and antiproteolytic activities that
determine extracellular matrix turnover. We examined the expression of plasminogen
activator-plasmin system components in experimental liver fibrosis of rats. Methods: Liver
fibrosis was produced in rats by injecting carbon tetrachloride for 6 to 12 weeks. Gene
expression for plasminogen activator inhibitor-1 (PAI-1), urokinase and tissue plasminogen …
important regulators of the balance between the proteolytic and antiproteolytic activities that
determine extracellular matrix turnover. We examined the expression of plasminogen
activator-plasmin system components in experimental liver fibrosis of rats. Methods: Liver
fibrosis was produced in rats by injecting carbon tetrachloride for 6 to 12 weeks. Gene
expression for plasminogen activator inhibitor-1 (PAI-1), urokinase and tissue plasminogen …