Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an update
M Van Meijer, H Pannekoek - Fibrinolysis, 1995 - Elsevier
Recent evidence has certified that plasminogen activator inhibitor 1 (PAI-1) is a major
regulatory protein of the fibrinolytic system in vivo. It rapidly inactivates both tissue-type (t-
PA) and urokinase-type plasminogen activator (u-PA). PAI-1 belongs to the serine protease
inhibitor ('serpin') superfamily of homologous proteins. X-ray diffraction analysis on crystals
of several active and inactive serpins (eg PAI-1) has taught us essential features of the three-
dimensional structure of these molecules. Moreover, it has provided a rationale for the …
regulatory protein of the fibrinolytic system in vivo. It rapidly inactivates both tissue-type (t-
PA) and urokinase-type plasminogen activator (u-PA). PAI-1 belongs to the serine protease
inhibitor ('serpin') superfamily of homologous proteins. X-ray diffraction analysis on crystals
of several active and inactive serpins (eg PAI-1) has taught us essential features of the three-
dimensional structure of these molecules. Moreover, it has provided a rationale for the …