[HTML][HTML] Integration of Jak-Stat and AP-1 signaling pathways at the vasoactive intestinal peptide cytokine response element regulates ciliary neurotrophic factor …
A Symes, T Gearan, J Eby, JS Fink - Journal of Biological Chemistry, 1997 - ASBMB
Ciliary neurotrophic factor (CNTF)-dependent induction of expression of the neuropeptide
vasoactive intestinal peptide (VIP) gene is mediated by a 180-base pair cytokine response
element (CyRE) in the VIP promoter. To elucidate the molecular mechanisms mediating the
transcriptional activation by CNTF, intracellular signaling to the CyRE has been studied in a
neuroblastoma cell line. It has been shown previously that CNTF induces Stat proteins to
bind to a site within the CyRE. CNTF also induces a second protein to bind to a C/EBP-like …
vasoactive intestinal peptide (VIP) gene is mediated by a 180-base pair cytokine response
element (CyRE) in the VIP promoter. To elucidate the molecular mechanisms mediating the
transcriptional activation by CNTF, intracellular signaling to the CyRE has been studied in a
neuroblastoma cell line. It has been shown previously that CNTF induces Stat proteins to
bind to a site within the CyRE. CNTF also induces a second protein to bind to a C/EBP-like …