Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system

P Carmeliet, D Collen - Thrombosis research, 1998 - thrombosisresearch.com
Initiation of the plasma coagulation system is trigplasminogen (Plg), the matrix
metalloproteinase gered by tissue factor (TF), which functions as a (MMP), and the
coagulation system and to a limited cellular receptor and cofactor for activation of the extent,
on the cathepsin proteinases, as deduced serine proteinase factor VII (FVII) to factor VIIa
from recent gene targeting and transfer studies in (FVIIa)[1–4]. Activation of factor VII can be
performed by FVIIa (autoactivation), factor IX, factor X, factor XII, thrombin, or hepsin [2]. The …