Many signals that cause apoptotic cell death operate by inducing transcription and
translation of other (presumably death effector) mediators, and it is well established that
stimulus-induced apoptosis can often be blocked by inhibiting transcription and translation.
Transcriptional regulation of apoptosis, however, is incompletely understood. To gain insight
into nuclear events associated with signal-induced apoptosis during T cell development, we
studied signal-induced apoptosis of ex vivo isolated immature CD8+ 4+ double-positive …