Complement and the immune response
MC Carroll, MB Fischer - Current opinion in immunology, 1997 - Elsevier
MC Carroll, MB Fischer
Current opinion in immunology, 1997•ElsevierThis past year has seen a major advance in our understanding of how the complement
system enhances the adaptive immune response. The use of in vivo models has revealed
that direct coupling of C3d to antigen is sufficient to dramatically reduce the amount of
antigen required for a secondary response. At least one important requirement for the
enhancing effect was determined to be expression of the CD21 (C3d receptor) on B cells.
system enhances the adaptive immune response. The use of in vivo models has revealed
that direct coupling of C3d to antigen is sufficient to dramatically reduce the amount of
antigen required for a secondary response. At least one important requirement for the
enhancing effect was determined to be expression of the CD21 (C3d receptor) on B cells.
This past year has seen a major advance in our understanding of how the complement system enhances the adaptive immune response. The use of in vivo models has revealed that direct coupling of C3d to antigen is sufficient to dramatically reduce the amount of antigen required for a secondary response. At least one important requirement for the enhancing effect was determined to be expression of the CD21 (C3d receptor) on B cells.
Elsevier