Increases in osteocalcin after ovariectomy are amplified by LPS injection: strain differences in bone remodelling
R Blanque, C Cottereaux, CR Gardner - General Pharmacology: The …, 1998 - Elsevier
1. LPS (Escherichia coli serotype 0111: B4, 300 μg/mouse IP) increases serum osteocalcin
in normal female C57B16 mice from 2 to 6 hr after its injection, with peak levels at 2–4 hr
after LPS. 2. 2. Both basal and LPS-stimulated serum osteocalcin were markedly inhibited
by dexamethasone (10 mg/kg IP). 3. 3. When observed 3 hr after LPS injection, serum
osteocalcin was increased by ovariectomy (OVX)(with respect to sham-operated mice) and
this increase was amplified in LPS-treated mice. This increase in osteocalcin was maximal …
in normal female C57B16 mice from 2 to 6 hr after its injection, with peak levels at 2–4 hr
after LPS. 2. 2. Both basal and LPS-stimulated serum osteocalcin were markedly inhibited
by dexamethasone (10 mg/kg IP). 3. 3. When observed 3 hr after LPS injection, serum
osteocalcin was increased by ovariectomy (OVX)(with respect to sham-operated mice) and
this increase was amplified in LPS-treated mice. This increase in osteocalcin was maximal …