The role of genomic imprinting of Gsα in the pathogenesis of Albright hereditary osteodystrophy
LS Weinstein, S Yu - Trends in Endocrinology & Metabolism, 1999 - cell.com
LS Weinstein, S Yu
Trends in Endocrinology & Metabolism, 1999•cell.comAlbright hereditary osteodystrophy (AHO) is caused by heterozygous inactivating mutations
of the gene encoding the α-subunit of the G protein G s. The G s α gene is a complex gene
that uses various alternative promoters and produces various protein products. Recently, it
has been shown that this gene is imprinted in a tissue-specific manner. The role of tissue-
specific imprinting of G s α in the pathogenesis of AHO is discussed.
of the gene encoding the α-subunit of the G protein G s. The G s α gene is a complex gene
that uses various alternative promoters and produces various protein products. Recently, it
has been shown that this gene is imprinted in a tissue-specific manner. The role of tissue-
specific imprinting of G s α in the pathogenesis of AHO is discussed.
Abstract
Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivating mutations of the gene encoding the α-subunit of the G protein Gs. The Gsα gene is a complex gene that uses various alternative promoters and produces various protein products. Recently, it has been shown that this gene is imprinted in a tissue-specific manner. The role of tissue-specific imprinting of Gsα in the pathogenesis of AHO is discussed.
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