[HTML][HTML] Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain: BIOCHEMICAL AND IMMUNOCYTOCHEMICAL ANALYSIS WITH ANTIBODIES SPECIFIC FOR FORMS …
Biochemical and immunocytochemical analyses were performed to evaluate the
composition of the amyloid β protein (Aβ) deposited in the brains of patients with Alzheimer's
disease (AD). To quantitate all Aβs present, cerebral cortex was homogenized in 70% formic
acid, and the supernatant was analyzed by sandwich enzyme-linked immunoabsorbent
assays specific for various forms of Aβ. In 9 of 27 AD brains examined, there was minimal
congophilic angiopathy and virtually all Aβ (96%) ended at Aβ42 (43). The other 18 AD …
composition of the amyloid β protein (Aβ) deposited in the brains of patients with Alzheimer's
disease (AD). To quantitate all Aβs present, cerebral cortex was homogenized in 70% formic
acid, and the supernatant was analyzed by sandwich enzyme-linked immunoabsorbent
assays specific for various forms of Aβ. In 9 of 27 AD brains examined, there was minimal
congophilic angiopathy and virtually all Aβ (96%) ended at Aβ42 (43). The other 18 AD …