C1q is a nucleotide binding protein and is responsible for the ability of clusterin preparations to promote immune complex formation
PJ Roeth, SB Easterbrook-Smith - Biochimica et Biophysica Acta (BBA) …, 1996 - Elsevier
Clusterin prepared from human serum by monoclonal antibody affinity chromatography was
devoid of the ability to increase the rates of formation of insoluble immune complexes
associated with clusterin preparations obtained by polyclonal IgG affinity chromatography.
Clusterin did not bind to AMP-Sepharose but the protein responsible for increasing the rates
of formation of insoluble immune complexes did bind to this affinity matrix. This protein was
identified as complement protein C1q on the basis of its behaviour on SDS/PAGE and …
devoid of the ability to increase the rates of formation of insoluble immune complexes
associated with clusterin preparations obtained by polyclonal IgG affinity chromatography.
Clusterin did not bind to AMP-Sepharose but the protein responsible for increasing the rates
of formation of insoluble immune complexes did bind to this affinity matrix. This protein was
identified as complement protein C1q on the basis of its behaviour on SDS/PAGE and …