Clusterin, a glycoprotein with potent cellular cohesive properties, is induced in many organs
at times of tissue injury or remodeling. After renal infarction, for example, clusterin is
localized to tubular epithelial cells in the peri-infarct zone. The purpose of this study was to
examine the spatial and temporal expression of cardiac clusterin after myocardial infarction.
Sprague-Dawley rats underwent permanent coronary ligation or sham operation. Hearts
were harvested at 6 hours and at 2, 14, and 28 days after infarction. Cardiac clusterin …