NF-κB is a potential target for immunosuppressive therapy. Two methods were evaluated to
inhibit NF-κB: the antisense (AS) approach in which single-stranded oligodeoxynucleotides
(ODNs) bind the mRNA for the RelA subunit of NF-κB and the transcription factor decoy
(TFD) approach in which double-stranded ODNs bind the NF-κB protein. AS and TFD
inhibited NF-κB binding and decreased total IgG and anti-dsDNA antibody production in
splenocytes from the BXSB/Yaaautoimmune mouse strain. TNF-α expression was reduced …