[HTML][HTML] Osmotic response element enhancer activity: Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase
Hypertonicity induces a group of genes that are responsible for the intracellular
accumulation of protective organic osmolytes such as sorbitol and betaine. Two
representative genes are the aldose reductase enzyme (AR, EC 1.1. 1.21), which is
responsible for the conversion of glucose to sorbitol, and the betaine transporter (BGT1),
which mediates Na+-coupled betaine uptake in response to osmotic stress. We recently
reported that the induction of BGT1 mRNA in the renal epithelial Madin-Darby canine kidney …
accumulation of protective organic osmolytes such as sorbitol and betaine. Two
representative genes are the aldose reductase enzyme (AR, EC 1.1. 1.21), which is
responsible for the conversion of glucose to sorbitol, and the betaine transporter (BGT1),
which mediates Na+-coupled betaine uptake in response to osmotic stress. We recently
reported that the induction of BGT1 mRNA in the renal epithelial Madin-Darby canine kidney …