[HTML][HTML] Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of …
CC Chen, KT Chiu, YT Sun, WC Chen - Journal of Biological Chemistry, 1999 - ASBMB
The signaling pathway for lipopolysaccharide (LPS)-induced nitric oxide (NO) release in
RAW 264.7 macrophages involves the protein kinase C and p38 activation pathways (Chen,
CC, Wang, JK, and Lin, SB (1998) J. Immunol. 161, 6206–6214; Chen, CC, and Wang, JK
(1999) Mol. Pharmacol. 55, 481–488). In this study, the role of the cAMP-dependent protein
kinase A (PKA) pathway was investigated. The PKA inhibitors, KT-5720 and H8, reduced
LPS-induced NO release and inducible nitric oxide synthase (iNOS) expression. The direct …
RAW 264.7 macrophages involves the protein kinase C and p38 activation pathways (Chen,
CC, Wang, JK, and Lin, SB (1998) J. Immunol. 161, 6206–6214; Chen, CC, and Wang, JK
(1999) Mol. Pharmacol. 55, 481–488). In this study, the role of the cAMP-dependent protein
kinase A (PKA) pathway was investigated. The PKA inhibitors, KT-5720 and H8, reduced
LPS-induced NO release and inducible nitric oxide synthase (iNOS) expression. The direct …