[HTML][HTML] Sphingosine 1-phosphate stimulates cell migration through a Gi-coupled cell surface receptor: potential involvement in angiogenesis
F Wang, JR Van Brocklyn, JP Hobson… - Journal of Biological …, 1999 - ASBMB
Sphingosine 1-phosphate (SPP) has been shown to inhibit chemotaxis of a variety of cells,
in some cases through intracellular actions, while in others through receptor-mediated
effects. Surprisingly, we found that low concentrations of SPP (10–100 nm) increased
chemotaxis of HEK293 cells overexpressing the G protein-coupled SPP receptor EDG-1. In
agreement with previous findings in human breast cancer cells (Wang, F., Nohara, K.,
Olivera, O., Thompson, EW, and Spiegel, S.(1999) Exp. Cell Res. 247, 17–28), SPP, at …
in some cases through intracellular actions, while in others through receptor-mediated
effects. Surprisingly, we found that low concentrations of SPP (10–100 nm) increased
chemotaxis of HEK293 cells overexpressing the G protein-coupled SPP receptor EDG-1. In
agreement with previous findings in human breast cancer cells (Wang, F., Nohara, K.,
Olivera, O., Thompson, EW, and Spiegel, S.(1999) Exp. Cell Res. 247, 17–28), SPP, at …