Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants
J Herbert, B Roser - Transplantation, 1988 - journals.lww.com
J Herbert, B Roser
Transplantation, 1988•journals.lww.comAbstract Treatment of normal rats with certain monoclonal anti-CD4 antibodies, beginning
on the day of grafting, prevents heart graft rejection across a full MHC-haplotype mismatch.
Adequate doses of antibody MRC OX-35, which is very potent in vivo, led to the induction of
authentic specific tolerance of the transplants. In the very stringent grafting test of
transplantation of DA skin to high-responder LOU recipients, adjunctive therapy with
cyclosporine, in addition to the anti-CD4 antibodies, is required to induce tolerance. Since …
on the day of grafting, prevents heart graft rejection across a full MHC-haplotype mismatch.
Adequate doses of antibody MRC OX-35, which is very potent in vivo, led to the induction of
authentic specific tolerance of the transplants. In the very stringent grafting test of
transplantation of DA skin to high-responder LOU recipients, adjunctive therapy with
cyclosporine, in addition to the anti-CD4 antibodies, is required to induce tolerance. Since …
Abstract
Treatment of normal rats with certain monoclonal anti-CD4 antibodies, beginning on the day of grafting, prevents heart graft rejection across a full MHC-haplotype mismatch. Adequate doses of antibody MRC OX-35, which is very potent in vivo, led to the induction of authentic specific tolerance of the transplants. In the very stringent grafting test of transplantation of DA skin to high-responder LOU recipients, adjunctive therapy with cyclosporine, in addition to the anti-CD4 antibodies, is required to induce tolerance. Since tolerance persists indefinitely after a 30-day course of treatment and appears to involve T cell-mediated suppression, this form of treatment is of potential clinical interest.
Lippincott Williams & Wilkins